Table 2.
Characteristics of the major clinical phenotypes
| Parameter | N | CM | N | SMA | N | UM | N | RD | P-value |
|---|---|---|---|---|---|---|---|---|---|
| Hyperpyrexia, n (%) |
47 |
9 (19.1) |
191 |
24 (12.6) |
154 |
29 (18.8) |
32 |
9 (28.1) |
0.110 |
| Hyperparasitaemia, n (%) |
48 |
6 (12.5) |
231 |
5 (2.2) |
228 |
14 (6.1) |
26 |
3 (11.5) |
0.008 |
| Hypoglycaemia, n (%) |
49 |
- |
187 |
24 (12.8) |
177 |
18 (10.2) |
26 |
4 (15.4) |
0.617 |
| Fatality, n (%) |
47 |
11 (23.4) |
187 |
11 (5.4) |
154 |
3 (1.9) |
33 |
5 (15.2) |
<0.001 |
| Mean age ± SD (months) |
49 |
37.85 ± 30.15 |
205 |
29.96 ± 27.33 |
201 |
51.41 ± 38.81♣ |
33 |
40.28 ± 34.33 |
<0.001 |
| Mean haemoglobin ± SD (g/dl) |
49 |
6.29 ± 2.34 |
225 |
3.65 ± 0.83 |
222 |
9.60 ± 1.31 |
31 |
7.71 ± 2.27 |
<0.001 |
| *GMPD, parasites/μL |
48 |
8,578 |
231 |
7,754 |
228 |
6,791 |
26 |
17,512 |
0.346 |
| Mean spleen size ± SD (cm) |
41 |
0.95 ± 1.66 |
124 |
1.51 ± 2.37 |
104 |
1.08 ± 1.94 |
15 |
3.13 ± 3.04§ |
0.004 |
| Mean plasma glucose ± SD (mmol/l) | 49 | 6.41 ± 3.57 | 187 | 5.91 ± 4.41 | 177 | 6.23 ± 6.33 | 26 | 4.63 ± 4.25 | 0.474 |
♣Age significantly higher than the corresponding values for SMA (P < 0.001) and CM (P = 0.050).
§Spleen size significantly higher than the corresponding values for CM (P = 0.005), SMA (P = 0.033) and UM (P = 0.004).
The haemoglobin values are significantly different between all four clinical groups; each participant has been categorised into one group only which clinicians felt was the primary phenotype. Samples numbers in some of the clinical groups are lower because some parameter estimates were not taken.