Table II.
The diagnostic accuracy of the cytokines.
| Bone invasion (by H&E)
|
P-valuea | Specificity | Sensitivity | Positive predictive value | Negative predictive value | |||
|---|---|---|---|---|---|---|---|---|
| + | − | Total | ||||||
| IL-1α | ||||||||
| + | 5 | 0 | 5 | |||||
| − | 3 | 11 | 14 | 0.0048 | 1 | 0.63 | 1 | 0.79 |
| 8 | 11 | 19 | ||||||
| IL-6 | ||||||||
| + | 3 | 1 | 4 | |||||
| − | 5 | 9 | 14 | 0.2745 | 0.90 | 0.38 | 0.75 | 0.64 |
| 8 | 10 | 18 | ||||||
| OPG | ||||||||
| + | 9 | 5 | 14 | |||||
| − | 1 | 13 | 14 | 0.0044 | 0.72 | 0.90 | 0.64 | 0.93 |
| 10 | 18 | 28 | ||||||
| RANK | ||||||||
| + | 4 | 1 | 5 | |||||
| − | 1 | 6 | 7 | 0.0720 | 0.86 | 0.8 | 0.80 | 0.86 |
| 5 | 7 | 12 | ||||||
| RANKL | ||||||||
| + | 10 | 7 | 17 | |||||
| − | 2 | 11 | 13 | 0.0256 | 0.61 | 0.83 | 0.59 | 0.85 |
| 12 | 18 | 30 | ||||||
| PTHrP | ||||||||
| + | 8 | 1 | 9 | |||||
| − | 1 | 10 | 11 | 0.0009 | 0.91 | 0.89 | 0.89 | 0.91 |
| 9 | 11 | 20 | ||||||
| TNF-α | ||||||||
| + | 5 | 2 | 7 | |||||
| − | 4 | 9 | 13 | 0.1597 | 0.82 | 0.56 | 0.71 | 0.69 |
| 9 | 11 | 20 | ||||||
a
By Fisher's exact test. Values in bold are significant.