Figure 1.
Effects of telmisartan on early and late apoptosis as shown by flow cytometry. Treatment with 100 μM telmisartan induced early apoptosis in almost the total percentage of the urological cancer cell lines. The top left quadrants represent early apoptosis (Annexin V-FITC-positive and PI-negative cells). The top right quadrants represent late apoptosis and necrosis (Annexin V-FITC-positive and PI-positive cells). Typical flow cytometry analysis histograms in a representative experiment are shown (A, Caki-1; B, T24; C, LNCaP; D, PC3; E, DU-145; F, NEC-8).