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Schematic diagram of glutamate synapses showing potential sites of interaction for modulation of NMDAR function. mGlu, metabotropic glutamate receptor; nACh7, alpha7 nicotinic receptor; EAAT, excitatory amino acid transporter; GlyT1, glycine type 1 transporter; SerT, high-affinity D-serine transporter; Xc–, cystine/glutamate antiporter; Glu, glutamate; Gly, glycine; D-ser, D-serine; GSH, glutathione. Adapted from Javitt et al. 27
