Table 2.

Foci Showing Significant Group Differences in Whole-Brain Amygdala Task-Based Functional Connectivity

X	Y	Z	Hemisphere	Anatomical Landmark	Region Size (mm cubic)	Peak Z-score
Bilateral amygdala SCZ vs CON—negative condition
SCZ > CON
56	−25	−14	Right	Middle temporal gyrus	3024	3.90
−62	−45	−10	Left	Middle temporal gyrus	1458	3.91
−24	46	26	Left	Superior frontal gyrus	351	4.54
23	47	29	Right	Superior frontal gyrus	378	4.15
17	28	37	Right	Middle frontal gyrus	621	4.47
−28	29	39	Left	Middle frontal gyrus	378	3.70
−19	23	51	Left	Superior frontal gyrus	621	4.20
7	16	51	Left	Superior frontal gyrus	1620	4.26
−6	39	52	Right	Superior frontal gyrus	3699	3.81
CON > SCZ
25	−46	−27	Right	Cerebellum	405	−3.54
−17	−84	10	Left	Cuneus	513	−3.91
−24	−84	22	Left	Middle occipital gyrus	378	−4.96
Bilateral amygdala SCZ vs CON—negative minus neutral contrast (interaction test)
−27	−36	−26	Left	Cerebellum	810	4.07
2	−23	18	Right	Medial dorsal thalamus	864	4.34
13	39	23	Right	Medial frontal gyrus	432	4.26
−22	−74	23	Left	Precuneus	432	3.24
−27	48	25	Left	Superior frontal gyrus	702	4.02
-5	33	31	Right	Medial frontal gyrus	594	3.85
15	32	35	Right	Medial frontal gyrus	891	3.93
−11	42	43	Left	Superior frontal gyrus	3537	4.23
−20	25	50	Left	Superior frontal gyrus	378	3.46
5	23	57	Right	Superior frontal gyrus	702	4.03

Note: Top panel shows group differences using random-effects independent samples t-tests for negative condition specifically. Bottom panel shows the results of the interaction test (ie, Controls vs. Patients for Negative Minus Neutral Contrast). All reported foci met appropriate whole-brain type I error correction (z > 3.00, k = 13, Corresponding to P < .05, Monte Carlo Corrected Given Employed Smoothing Level). SCZ, patients with schizophrenia; CON, controls.