Table 2.

Potential targets for premarital carrier screening in Arabic LMICs

Disease	Inheritance	OMIM no.	Carrier frequency in Arab populations [35,55]
Sickle cell disease	AR	603903	0.3% to 30%
Beta-thalassemia	AR	613985	2% to 7%
Alpha-thalassemia	AR	604131	2% to 50%
Cystic fibrosis	AR	219700	1/25 to 1/50
Spinal muscular atrophy	AR	253300	1/25 to 1/60

AR, autosomal recessive; LMICs, low- and middle-income countries; OMIM, Online Mendelian Inheritance in Man [54].