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. 2012 May 25;14(3):R86. doi: 10.1186/bcr3201

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Copyright ©2012 Ottewell et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of plakoglobin expression on tumor cell invasion, migration, and expression of the tumor-suppressor gene NM23-H1. (A, B) Histograms of mean ± SEM percentage of MCF7 (A) and T47D (B) tumor cell invasion through a basement membrane matrix (Matrigel)-coated membrane compared with an uncoated membrane. Histograms showing mean ± SEM percentage of wound closure by MCF7 cells 24, 48, and 72 hours after scratch (C), and T47D cells 24 and 48 hours after scratch (D). (E) Expression of the tumor-suppressor gene, NM23-H1, in control and plakoglobin-knockdown MCF7 and T47D cells. (*P < 0.005, by one-way ANOVA followed by the Dunnett two-sided multiple-comparison test).