Table 3.
Sensitivity (per-patient) and specificity using BI-RADS score of at least 4 to define a positive test
| Reader | MX ± US | MX ± US ± CEDM | Difference | P value |
|---|---|---|---|---|
| Sensitivity | ||||
| 1 | 0.875 ± 0.042 | 0.922 ± 0.034 | 0.047 | 0.25 |
| 2 | 0.953 ± 0.027 | 0.938 ± 0.030 | -0.016 | 1.00 |
| 3 | 0.922 ± 0.034 | 0.938 ± 0.030 | 0.016 | 1.00 |
| 4 | 0.969 ± 0.022 | 0.953 ± 0.027 | -0.016 | 1.00 |
| 5 | 0.938 ± 0.030 | 0.859 ± 0.044 | -0.078 | 0.07 |
| 6 | 0.875 ± 0.042 | 0.906 ± 0.037 | 0.031 | 0.68 |
| Overall | 0.922 ± 0.028 | 0.919 ± 0.031 | -0.003 ± 0.022 | 0.91 |
| 95% CI | 0.866 to 0.977 | 0.858 to 0.981 | -0.052 to 0.047 | |
| Specificity | ||||
| 1 | 0.565 ± 0.074 | 0.457 ± 0.074 | -0.109 | 0.18 |
| 2 | 0.478 ± 0.074 | 0.587 ± 0.073 | 0.109 | 0.23 |
| 3 | 0.413 ± 0.073 | 0.457 ± 0.074 | 0.043 | 0.68 |
| 4 | 0.174 ± 0.057 | 0.239 ± 0.064 | 0.065 | 0.37 |
| 5 | 0.326 ± 0.07 | 0.413 ± 0.073 | 0.087 | 0.34 |
| 6 | 0.565 ± 0.074 | 0.609 ± 0.073 | 0.043 | 0.77 |
| Overall | 0.42 ± 0.073 | 0.46 ± 0.071 | 0.040 | 0.336 |
| 95% CI | 0.262 to 0.578 | 0.308 to 0.613 | -0.046 to 0.126 | |
Values are presented as estimate ± standard error unless otherwise indicated. BI-RADS, Breast Imaging, Reporting and Data System; CEDM, contrast-enhanced digital mammography; CI, confidence interval; MX, mammography; US, ultrasonography.