Table 2.
Estimated life span of protective and autoreactive humoral immunity during long-term B-cell depletiona
| Individual data analysis | |||
|---|---|---|---|
| Pooled data analysis b | Life span in years c | ||
| Median life span in years (Spearman's ρ) d | Median (range) | Spearman's ρ (range) d | |
| Total IgG | 38.3 (0.89) | 35.5 (10.1 to ∞) | 0.75 (0.09 to 0.99) |
| ACPA-IgG | 9.08 (0.89) | 10.1 (5.22 to ∞) | 0.83 (0.48 to 1.0) |
| Measles-IgG | ∞ (0.66) | ∞ (15.9 to ∞) | 0.48 (0.01 to 0.92) |
| Mumps-IgG | ∞ (0.90) | ∞ (24.0 to ∞) | 0.60 (0.04 to 0.84) |
| Rubella-IgG | 75.5 (0.35) | 153 (9.03 to ∞) | 0.41 (0.04 to 0.93) |
| Total IgM | 12.3 (0.96) | 10.6 (6.0 to 36.7) | 0.83 (0.38 to 1.0) |
| ACPA-IgM | 11.7 (1.0) | 14.9 (5.71 to ∞) | 0.88 (0.07 to 0.99) |
| RF-IgM | 4.78 (0.96) | 5.27 (4.35 to 7.20) | 0.94 (0.68 to 0.99) |
| Total IgA | 33.5 (0.85) | 22.8 (8.47 to ∞) | 0.77 (0.26 to 0.95) |
| ACPA-IgA | 9.48 (0.71) | 9.33 (6.15 to 48.4) | 0.88 (0.16 to 0.98) |
aACPA = anticitrullinated peptide antibody; Ig = immunoglobulin; RF = rheumatoid factor. bLife span was estimated using the median data for all patients pooled together as depicted in Figure 3. cLife span was estimated for each individual patient, here summarised in the depicted medians (ranges). dSpearman's ρ data are correlation coefficients of the linear curves used to estimate the life span, which is explained in the Methods section.