Table 2.
Percentages of cytokine-producing CCR4+ and/or CCR6+ cell subsets within the total CD4+ T cell population compared with the CCR4-CCR6- cell subset
| Granulomatosis with polyangiitis | ||||
|---|---|---|---|---|
| CCR4-CCR6- cells | CCR4+CCR6- cells | CCR4-CCR6+ cells | CCR4+CCR6+ cells | |
| Percentage of IFNγ+ cells | 11.3 ± 5.1 | 5.5 ± 2.0 | 28.2 ± 4.3 | 4.0 ± 0.5 |
| Percentage of IL-4+ cells | 1.0 ± 0.5 | 5.5 ± 1.5a | 0.6 ± 0.3 | 1.0 ± 0.4 |
| Percentage of IL-17+ cells | 0.1 ± 0.0 | 0.1 ± 0.0 | 7.8 ± 1.8a | 9.5 ± 0.9b |
| Percentage of IL-22+ cells | 0.1 ± 0.0 | 0.2 ± 0.1 | 2.4 ± 0.5a | 3.4 ± 0.6a |
| Healthy controls | ||||
| CCR4-CCR6- cells | CCR4+CCR6- cells | CCR4-CCR6+ cells | CCR4+CCR6+ cells | |
| Percentage of IFNγ+ cells | 21.7 ± 8.4 | 13.1 ± 2.0 | 30.7 ± 1.1 | 6.0 ± 0.5 |
| Percentage of IL-4+ cells | 1.0 ± 0.3 | 5.4 ± 1.0a | 1.5 ± 0.4 | 2.2 ± 0.6 |
| Percentage of IL-17+ cells | 0.1 ± 0.0 | 0.2 ± 0.0 | 9.1 ± 1.0a | 9.7 ± 1.8a |
| Percentage of IL-22+ cells | 0.1 ± 0.0 | 0.4 ± 0.2 | 3.3 ± 0.9a | 5.0 ± 2.1a |
Percentages of positive cells were assessed by flow cytometry. Values are expressed as mean ± standard error of the mean. aP < 0.5, bP < 0.01, Mann-Whitney U test. CCR, CC chemokine receptor; IFNγ, interferon-gamma; IL, interleukin.