Table 4.
Association of TGFB1 heterozygous genotypes with ischaemic heart disease and myocardial infarction in rheumatoid arthritis patients stratified by ever smoking
| Ischemic heart disease | Myocardial infarction | |||||
|---|---|---|---|---|---|---|
| Negative | Positive | OR (95% CI) | Negative | Positive | OR (95% CI) | |
| Smoke/-509 CT | ||||||
| -/- | 65 (89.0%) | 8 (11.0%) | 1.0 (referent) | 70 (95.9%) | 3 (4.1%) | 1.0 (referent) |
| -/+ | 58 (89.2%) | 7 (10.8%) | 0.99 (0.35-2.80) | 61 (93.8%) | 4 (6.2%) | 1.47 (0.35-6.21) |
| +/- | 124 (78.5%) | 34 (21.5%) | 2.14 (0.95-4.79) | 137 (86.7%) | 21 (13.3%) | 3.15 (0.98-10.10) |
| +/+ | 81 (68.6%) | 37 (31.4%) | 3.55 (1.57-7.99) AP: 0.41 (-0.03-0.84) |
94 (79.7%) | 24 (20.3%) | 5.22 (1.63-16.69) AP: 0.31 (-0.22-0.84) |
| Smoke/+868 TC | ||||||
| -/- | 68 (88.3%) | 9 (11.7%) | 1.0 (referent) | 74 (96.1%) | 3 (3.9%) | 1.0 (referent) |
| -/+ | 55 (90.2%) | 6 (9.8%) | 0.84 (0.29-2.43) | 57 (93.4%) | 4 (6.6%) | 1.67 (0.40-7.02) |
| +/- | 123 (82.6%) | 26 (17.4%) | 1.55 (0.70-3.44) | 133 (89.3%) | 16 (10.7%) | 2.63 (0.80-8.63) |
| +/+ | 82 (64.6%) | 45 (35.4%) | 3.98 (1.84-8.58) AP: 0.66 (0.34-0.97) |
98 (77.2%) | 29 (22.8%) | 6.37 (2.02-20.10) AP: 0.49 (0.08-0.91) |
'Negative' and 'positive' values are presented as number (percentage). AP, the attributable proportion due to interaction; CI, confidence interval; OR, odds ratio; TGFB1, transforming growth factor-beta-1.