. 2012 May 17;14(3):R117. doi: 10.1186/ar3847

Table 4.

Linear and binary regression between classical CVD risk and endothelial function in RA patients from the cross-sectional study

	Microvascular function		Macrovascular function
	Endothelium-dependent	Endothelium- independent	Endothelium- dependent	Endothelium- independent

CVD risk factors
Insulin	β = 0.13, P = 0.23	β = 0.04, P = 0.73	β = -0.04, P = 0.71	β = -0.25, R²= 0.065^a
HOMA	β = 0.09, P = 0.41	β = -0.01, P = 0.95	β = -0.06, P = 0.61	β = -0.23, R²= 0.052^a
QUICKI	β = -0.07, P = 0.53	β = -0.02, P = 0.88	β = 0.11, P = 0.30	β = 0.30, R²= 0.095^b
High cholesterol	OR = 1.01 (0.99-1.00)	OR = 1.00 (0.99-1.00)	OR = 1.08 (0.99-1.17)	OR = 1.09 (1.02-1.17)^a
Hypertension	OR = 1.00 (1.00-1.00)	OR = 1.00 (0.99-1.00)	OR = 1.08 (0.99-1.17)	OR = 1.07 (1.01-1.14)^a
Cigarette smoking	OR = 1.00 (1.00-1.00)	OR = 1.00 (1.00-1.00)	OR = 1.04 (0.97-1.13)	OR = 1.04 (0.99-1.10)
Global CVD risk
FRS	β = -0.26, R²= 0.068^b	β = -0.18, P = 0.09	β = -0.12, P = 0.26	β = -0.32, R²= 0.101^b
TC score	β = -0.28, R²= 0.077^a	β = -0.17, P = 0.18	β = -0.23, P = 0.08	β = -0.14, P = 0.30
TC/HDL score	β = -0.26, R²= 0.068^a	β = -0.17, P = 0.19	β = -0.25, P = 0.05	β = -0.17, P = 0.18
Reynolds Risk Score	β = -0.30, R²= 0.088^a	β = -0.12, P = 0.37	β = -0.27, R²= 0.072^a	β = -0.51, R²= 0.259^b
QRISK 2	β = -0.33, R²= 0.109^b	β = -0.19, P = 0.08	β = -0.22, R²= 0.048^a	β = -0.51, R²= 0.255^b

CVD risk factors and global CVD risk scores were entered as independent variables, and endothelial functions, as dependent variables in the linear and binary regression analysis. Odds ratio (OR) with 95% confidence interval is presented for all binary regression analysis. CVD, cardiovascular disease; FRS, Framingham risk score; HDL, high-density lipoprotein; HOMA, homeostasis model assessment; QUICKI, quantitative insulin sensitivity check index; SCORE, systematic coronary risk evaluation; TC, total cholesterol. ^aP < 0.05; ^bP < 0.01. R²value is shown for all significant associations only.