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. 2012 May 23;14(3):R123. doi: 10.1186/ar3853

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Copyright ©2012 Li et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Anti-CD200R1 antibody promoted T-cell receptor-driven proliferation of CD4⁺T cells in systemic lupus erythematosus patients. (A) In systemic lupus erythematosus (SLE) patients and healthy controls (HCs), no significant difference in proliferation of anti-CD3/CD28-stimulated CD4⁺T cells was found in the presence of CD200Fc or IgG control. (B) In SLE patients, anti-CD200R1 promoted anti-CD3/CD28-stimulated proliferation of CD4⁺T cells in a concentration-dependent manner, whereas this was not observed in HCs. Fluorescence-activated cell sorting (OK)plots are representative of five experiments performed on five SLE patients and HCs, respectively. CFSE, carboxyfluorescein diacetate succinimidyl ester.