Table 2.
Intimal TRAF6 | Subintimal TRAF6 | Total TRAF6 | ||||
---|---|---|---|---|---|---|
R | P | r | P | r | P | |
Synovial inflammation | ||||||
Synovitis score | 0.239 | 0.119 | 0.465 | 0.001** | 0.412 | 0.006** |
hyperplasia of intima | 0.232 | 0.130 | 0.277 | 0.068 | 0.269 | 0.077 |
Inflammatory cell infiltration | 0.164 | 0.286 | 0.450 | 0.002** | 0.367 | 0.014* |
Cellular density of the synovial stroma | 0.147 | 0.340 | 0.118 | 0.444 | 0.164 | 0.288 |
CD3+ T cells | 0.367 | 0.033* | 0.526 | 0.001** | 0.478 | 0.004** |
CD20+ B cell | 0.165 | 0.343 | 0.359 | 0.034* | 0.313 | 0.047* |
CD38+ plasma cells | 0.200 | 0.250 | 0.391 | 0.020* | 0.390 | 0.020** |
Subintimal CD68+ cells | 0.356 | 0.074 | 0.562 | 0.003* | 0.532 | 0.005** |
Intimal CD68+ cells | 0.631 | 0.000*** | 0.604 | 0.000*** | 0.636 | 0.000*** |
MCV | 0.578 | 0.005** | 0.522 | 0.013* | 0.569 | 0.006** |
CD79a+ B lineage cells | 0.154 | 0.426 | 0.417 | 0.024* | 0.398 | 0.032* |
Disease duration | -0.161 | 0.298 | -0.144 | 0.352 | -0.145 | 0.347 |
Disease activity | ||||||
DAS28CRP | -0.186 | 0.226 | -0.179 | 0.245 | -0.157 | 0.308 |
CRP | 0.102 | 0.513 | 0.103 | 0.510 | 0.128 | 0.413 |
ESR | -0.133 | 0.394 | -0.058 | 0.710 | -0.057 | 0.719 |
RF | -0.094 | 0.546 | -0.003 | 0.986 | 0.005 | 0.975 |
ACPA | -0.067 | 0.692 | 0.110 | 0.517 | 0.058 | 0.733 |
Joint destruction | ||||||
Joint space narrowing subscore | -0.182 | 0.238 | -0.103 | 0.508 | -0.106 | 0.493 |
Erosion subscore | -0.233 | 0.128 | -0.125 | 0.419 | -0.145 | 0.347 |
Total Sharp score | -0.182 | 0.238 | -0.076 | 0.622 | -0.085 | 0.583 |
▲ Spearman's rank order correlation test was used to assess the correlation between synovial TRAF6 expression and the histological, clinical or joint destruction parameters in 44 RA patients.
ACPA, anti-cyclic citrullinated peptide antibody; DAS28, Disease Activity Score 28-joint assessment; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; MCV, microvascular count;RA, rheumatoid arthritis; RF, rheumatoid factor; *P < 0.05, ** P < 0.01, *** P < 0.001.