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. 2012 Jun 4;14(3):R133. doi: 10.1186/ar3866

Table 2.

Correlation between synovial TRAF6 expression and parameters of inflammation or joint destruction in RA patients

Intimal TRAF6 Subintimal TRAF6 Total TRAF6

R P r P r P
Synovial inflammation
Synovitis score 0.239 0.119 0.465 0.001** 0.412 0.006**
hyperplasia of intima 0.232 0.130 0.277 0.068 0.269 0.077
Inflammatory cell infiltration 0.164 0.286 0.450 0.002** 0.367 0.014*
Cellular density of the synovial stroma 0.147 0.340 0.118 0.444 0.164 0.288
CD3+ T cells 0.367 0.033* 0.526 0.001** 0.478 0.004**
CD20+ B cell 0.165 0.343 0.359 0.034* 0.313 0.047*
CD38+ plasma cells 0.200 0.250 0.391 0.020* 0.390 0.020**
Subintimal CD68+ cells 0.356 0.074 0.562 0.003* 0.532 0.005**
Intimal CD68+ cells 0.631 0.000*** 0.604 0.000*** 0.636 0.000***
MCV 0.578 0.005** 0.522 0.013* 0.569 0.006**
CD79a+ B lineage cells 0.154 0.426 0.417 0.024* 0.398 0.032*

Disease duration -0.161 0.298 -0.144 0.352 -0.145 0.347

Disease activity
DAS28CRP -0.186 0.226 -0.179 0.245 -0.157 0.308
CRP 0.102 0.513 0.103 0.510 0.128 0.413
ESR -0.133 0.394 -0.058 0.710 -0.057 0.719
RF -0.094 0.546 -0.003 0.986 0.005 0.975
ACPA -0.067 0.692 0.110 0.517 0.058 0.733

Joint destruction
Joint space narrowing subscore -0.182 0.238 -0.103 0.508 -0.106 0.493
Erosion subscore -0.233 0.128 -0.125 0.419 -0.145 0.347
Total Sharp score -0.182 0.238 -0.076 0.622 -0.085 0.583

Spearman's rank order correlation test was used to assess the correlation between synovial TRAF6 expression and the histological, clinical or joint destruction parameters in 44 RA patients.

ACPA, anti-cyclic citrullinated peptide antibody; DAS28, Disease Activity Score 28-joint assessment; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; MCV, microvascular count;RA, rheumatoid arthritis; RF, rheumatoid factor; *P < 0.05, ** P < 0.01, *** P < 0.001.