Table 3.
Univariate associations between ADORA3 rs1544224 and disease activity.
| Variable | Genotypea | Allelic P value | ||
|---|---|---|---|---|
| 11 | 12 | 22 | ||
| SJC (28) | 2.9 ± 3.4 | 2.7 ± 3.9 | 3.0 ± 3.0 | 0.89 |
| 123 (54.7%) | 84 (37.6%) | 18 (8.2%) | ||
| TJC (28) | 2.5 ± 3.5 | 2.4 ± 3.9 | 1.7 ± 2.3 | 0.65 |
| 123 (54.7%) | 84 (37.6%) | 18 (8.2%) | ||
| DAS28 | 2.9 ± 1.2 | 2.9 ± 1.3 | 2.9 ± 1.1 | 0.99 |
| 123 (54.7%) | 84 (37.6%) | 18 (8.2%) | ||
| CRP | 1.2 ± 2.1 | 1.1 ± 1.4 | 1.1 ± 0.9 | 0.98 |
| 105 (46.7%) | 66 (29.3%) | 16 (7.1%) | ||
| Physicians global | 23.5 ± 19.5 | 22.0 ± 19.8 | 15.5 ± 12.7 | 0.26 |
| 123 (54.7%) | 84 (37.6%) | 18 (8.2%) | ||
| Physicians response to MTX | 22.9 ± 18.9 | 22.2 ± 20.7 | 14.5 ± 13.6 | 0.23 |
| 118 (52.4%) | 71 (9.3%) | 18 (8.2%) | ||
| Pain VAS | 23.6 ± 22.8 | 22.8 ± 23.9 | 20.1 ± 22.9 | 0.83 |
| 123 (54.7%) | 84 (37.6%) | 18 (8.2%) | ||
| Patient global | 26.4 ± 21.9 | 27.6 ± 24.6 | 23.7 ± 17.1 | 0.79 |
| 123 (54.7%) | 84 (37.6%) | 18 (8.2%) | ||
| mHAQ | 0.42 ± 0.49 | 0.42 ± 0.45 | 0.37 ± 0.47 | 0.89 |
| 123 (54.7%) | 84 (37.6%) | 18 (8.2%) | ||
a1 = major allele, 2 = minor allele of rs1544224. Top row mean ± SD, bottom row number of patients. CRP, C-reactive protein; DAS28, disease activity score in 28 joints; HAQ, Health Assessment Questionnaire; MTX, methotrexate; SD, standard deviation; SJC, swollen joint count; TJC, tender joint count; VAS, visual analog scale.