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Effect of HA injection on cartilage histopathology in the TTR model. (A) Typical Safranin O histology of femoral and tibial epiphyses from naïve joints and joints of TTR and TTR+HA groups (B). For each of the experimental groups, the mean (+/SD) cartilage volume was calculated from the area stained with Safranin O as described in the Methods. The dotted lines show typical selections of areas used for cartilage quantitation.
