Table 4.
QPCR of Adamts5 expression in cartilage/subchondral bone and meniscus/synovium
| CARTILAGE/SC BON | MENISCUS/SYNOVIUM | ||||
|---|---|---|---|---|---|
| Adamts5 | P | Fold 5 | Adamts5 | Fold5 | |
| ΔCT1 | ΔCT1 | ||||
| Naive | 8.85 (0.55) | 1.00 | 8.31 | 1.00 | |
| TTR | 5.94 (0.44) | .00173 | 7.51 | 1.90 | 85.1 |
| TTR+HA | 7.56 (0.86) | .0414 | 2.44 | 5.35 | 7.84 |
| TTR+SA | 6.22 (1.24) | .0094 | 6.20 | -0.17 | 357 |
1relative to GAPDH, mean (SD) ΔCT of 8 pools with 2 mice per pool for Naïve and 12 pools with 2 mice per pool for all 4 treatment groups.
2relative to GAPDH, mean (SD) ΔCT of 2 pools with 8 mice per pool for Naïve and 2 pools with 12 mice per pool for all 4 treatment groups. Values represent the average of the two pools, with the difference between duplicates being < 20% of average pool value. P-values: 3TTR vs Naive; 4TTR+HA or TTR+SA vs TTR;
5Fold Changes are relative to Naive