Table 5.
QPCR of mmp13 expression in cartilage/subchondral bone and meniscus/synovium
| CARTILAGE/SC BONE | MENISCUS/SYNOVIUM | ||||
|---|---|---|---|---|---|
| mmp13 | P | Fold 5 | mmp13 | Fold5 | |
| ΔCT1 | ΔCT1 | ||||
| Naive | 4.74 (0.9) | 1.00 | 14.10 | 1.00 | |
| TTR | 1.95 (1.01) | .0043 | 5.73 | 9.56 | 23.3 |
| TTR+HA | 3.50 (1.11) | .0454 | 1.95 | 13.15 | 1.93 |
| TTR+SA | 1.12 (0.75) | .0034 | 12.30 | 7.89 | 74.4 |
1relative to gapdh, mean (SD) (Delta symbol) CT of 8 pools with 2 mice per pool for Naïve and 12 pools with 2 mice per pool for all 4 treatment groups.
2relative to gapdh, mean (SD) (Delta symbol) CT of 2 pools with 8 mice per pool for Naïve and 2 pools with 12 mice per pool for all 4 treatment groups. Values represent the average of the two pools, with the difference between duplicates being <20% of average pool value. p values: 3TTR vs Naive; 4TTR+HA or TTR+SA vs TTR; 5Fold Changes are relative to Naive.