Table 6.
Summary of tissue changes in the TTR model illustratesthe therapeutic effects of HA injection.
| TTR Relative to Naive |
TTR+HA Relative to TTR |
TTR+Saline Relative to TTR |
|
|---|---|---|---|
| CARTILAGE/SUBCHONDRAL BONE | |||
| Erosion | +++1 | --1 | Unchanged |
| Chondrogenic Genes | Unchanged | +++ | Unchanged |
| Fibrogenic Genes | +++ | --- | Unchanged |
| MMP Genes | +++ | --- | + |
| SYNOVIUM/MENISCUS | |||
| Perimeniscal Synovitis | +++ | -- | Unchanged |
| Chondrogenic Genes | +++ | --- | Unchanged |
| Fibrogenic Genes | +++ | --- | Unchanged |
| MMP Genes | +++ | --- | + |
1+/- = 2- to 4-fold Increase/decrease; ++/-- = 2- to 4-fold Increase/decrease; +++/--- = 5- to 10-fold increase