Table 2.

Comparison of the ACR/EULAR RA remission definition candidate for patients meeting ACR/EULAR classification criteria for rheumatoid arthritis (ESPOIR STUDY).

	Prevalence of good outcome in patients**:
Candidate remission definition (* definitions are those recommended by ACR/EULAR)	In remission	Not in remission *	Positive likelihood ratio *(95% CI)	P-value
Boolean-based definition
TJC28, SJC28, CRP ≤ 1	25% (29/118)	12%	1.4 (1.1, 1.7)	0.0526
TJC28, SJC28, CRP, PhGA ≤ 1	32% (23/71)	13%	1.9 (1.4, 2.7)	0.0034
TJC28, SJC28, CRP, PtGA ≤ 1*	39% (23/59)	12%	2.4 (1.6,3.5)	0.0002
TJC28, SJC28, CRP, pain ≤ 1	34% (24/70)	13%	2.0 (1.4, 2.8)	0.0023
TJC28, SJC28, CRP, PhGA, PtGA ≤ 1	40% (22/55)	12%	2.6 (1.7, 3.8)	0.0002
TJC28, SJC28, CRP, PhGA, pain ≤ 1	38% (21/55)	13%	2.3 (1.6, 3.5)	0.0006
TJC28, SJC28, CRP, PtGA, pain ≤ 1	40% (21/53)	12%	2.6 (1.7, 3.9)	0.0002
TJC28, SJC28, CRP, PhGA, PtGA, pain ≤ 1	39% (20/51)	13%	2.5 (1.6, 3.9)	0.0005
Index-based definition
DAS28 < 2.6	25% (35/146)	11%	1.3 (1.1, 1.5)	0.0383
DAS28 < 2.0	28% (24/85)	12%	1.6 (1.2, 2.2)	0.0148
SDAI ≤ 3.3*	39% (27/69)	12%	2.3 (1.6, 3.2)	0.0001
Definitions without CRP (for clinical practice)
TJC28, SJC28, PhGA, PtGA ≤ 1	38% (23/60)	13%	2.3(1.6,3.4)	0.0003
TJC28, SJC28, PtGA < 1*	37% (24/65)	12%	2.0(1.4,2.9)	0.0004
CDAI ≤ 2.8*	36% (26/72)	12%	2.0(1.5,2.8)	0.0005

*Average values calculated from the 500 bootstrap samples of patients not in remission.

**Good outcome defined in a person when they had both good function and good radiographic outcomes (see Methods). CDAI: clinical disease activity index; CRP: C-reactive protein; DAS: disease activity score; EULAR: European League Against Rheumatism; PtGA: patient global assessment; PhGA: physician global assessment; RA: rheumatoid arthritis; SJC28: 28 swollen joint count; TJC28: 28 tender joint count.