Table 2.
Replication and seroconversion of ferrets inoculated with or exposed to different H1N1 influenza viruses
| Virus | Viral titer (log10 EID50)a |
Seroconversion (positive/total)b |
Respiratory droplet transmission | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Nasal wash | Left lung |
Right lung |
Tonsil | ||||||||
| Lower | Middle | Upper | Lower | Middle | Upper | Inoculated (HI titer) | Exposed (HI titer) | ||||
| SC/09 | 5.3, 5.8 | 6.0, 8.3 | 6.0, 6.3 | 6.3, 3.8 | 6.3, 6.8 | 6.5, 4.8 | 4.5, 5.5 | 3.3, 2.8 | 3/3 (1,280) | 3/3 (1,280–2,560) | Efficient |
| HA/226R | 7.0, 6.8 | <, < | <, < | <, < | 2.5, < | <, < | <, < | 2.5, 1.3 | 3/3 (1,280–2,560) | 3/3 (2,560) | Less efficient |
| PB2/271T | 4.3, 6.3 | 4.5, < | 5.5, < | 5.3, < | 5.3, 5.5 | 4.8, < | 5.5, 3.5 | 3.5, 3.8 | 3/3 (1,280) | 3/3 (1,280–5,120) | Efficient |
| HA/226R+PB2/271T | 5.3, 7.0 | <, < | <, < | <, < | 2.8, < | <, < | <, < | 2.3, 0.8 | 3/3 (1,280) | 0/3 (<10) | None |
a
Groups of two ferrets were i.n. inoculated with 106 EID50 of each virus and euthanized on day 3 p.i.; nasal washes and the indicated organs were collected for virus titration in eggs. The individual titers of each ferret are presented. <, not detected in 0.1 ml of the undiluted nasal washes.