Table 2.
Correlations between HSV shedding or genital lesion rates and net cytokine expression by circulating, live, CD3+ CD8− CD4 T cells in response to UV-inactivated HSV-2 antigen
| IFN-γ, IL-2, and TNF-α expression by ICC | Median % of cells (range) | Pearson correlation coefficient (sig)a |
|
|---|---|---|---|
| HSV shedding | Genital lesions | ||
| Any cytokine expressed | 0.56 (0.08–4.73) | −0.14 (0.27) | −0.19 (0.13) |
| Any IFN-γ | 0.33 (0.04–3.77) | −0.11 (0.38) | −0.17 (0.17) |
| Any IL-2 | 0.30 (0.05–3.39) | −0.10 (0.40) | −0.14 (0.27) |
| Any TNF-α | 0.50 (0.04–4.66) | −0.16 (0.19) | −0.18 (0.15) |
| Single cytokine expressed | |||
| Only IFN-γ | 0.04 (0.00–0.38) | 0.10 (0.45) | −0.11 (0.40) |
| Only IL-2 | 0.01 (0.00–0.07) | −0.23 (0.33) | 0.01 (0.98) |
| Only TNF-α | 0.07 (0.00–1.24) | −0.19 (0.14) | −0.17 (0.20) |
| Two cytokines expressed | |||
| IFN-γ and IL-2 | 0.02 (0.00– 0.24) | 0.16 (0.20) | −0.08 (0.54) |
| IFN-γ and TNF-α | 0.09 (0.01– 0.78) | −0.14 (0.27) | −0.18 (0.14) |
| IL-2 and TNF-α | 0.07 (0.01– 0.38) | −0.07 (0.56) | −0.05 (0.71) |
| All three expressed | 0.17 (0.01– 2.98) | −0.14 (0.27) | −0.15 (0.25) |
a
sig, P value for test of null hypothesis that correlation equals 0.