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Viral-load-dependent effects of a PHx on HBV in mice. The hydrodynamic injection was used to introduce different amounts of the 1.3-mer HBV genomic DNA into the mouse liver. A PHx was performed on the mice 1 day after the DNA injection, and all of the mice were sacrificed 3 days after the PHx for the isolation of the liver for the analysis of the HBV RI DNA, RNAs, and the core protein as described in the Fig. 1 legend. −, with sham operation; +, with PHx.
