Table 1.
Clinically approved modulators of arachidonic acid derivatives.
| Drug class | COX inhibitors | Eicosanoid analogues | LOX inhibitors and leukotriene antagonists |
Phospholipase inhibitors |
|---|---|---|---|---|
| Examples | NSAIDS Selective COX-2 inhibitors (celecoxib) |
Misoprostol (PGE1) Latanoprost (F2α) Unoprostone (F2α) Travoprost (F2α) Iloprost (PGI2) Epoprostenol (PGI2) |
Zileuton Zafirlukast Montelukast |
Quinacrine Mepacrine Chloroquine |
|
| ||||
| Clinical applications | Analgesic Anti-inflammatory |
Pulmonary hypertension (iloprost, epoprostenol) Glaucoma (latanoprots, unoprostone) |
Asthma, allergic rhinitis, urticaria | Antiprotozoal Antirheumatic Antimalarial |
|
| ||||
| Routes of administration | Oral, parenteral | Inhaled, parenteral, topical | Oral | Oral |
|
| ||||
| Notes | Zafirlukast and Montelukast are cysteinyl leukotriene receptor CysLT1 antagonists | |||
NSAID: nonsteroidal anti-inflammatory drugs; PGI: prostacyclin.