Table 2.

Selected animal and human therapeutic studies.

Reference number	Model	Intervention	Outcome
[26]	Spinal cord injury in rats	Indomethacin and ibuprofen (COX inhibitors)	Increased functional recovery and axonal regeneration
[28]	Sciatic nerve crush in rats	Celecoxib (COX2 inhibitor)	Improved functional recovery
[38]	Sciatic nerve crush in diabetic rats	PGE1	Improved axonal regeneration
[37]	Sciatic nerve constriction injury in rats	PGE agonist	Decreased neuronal apoptosis
[35]	Sciatic nerve injury in rats	Alprostadil (PGE)	Decreased injury and improved functional recovery
[34]	Sciatic nerve ischemia-reperfusion injury in rats	Alprostadil	Decreased injury
[69]	Carpal tunnel syndrome. Human clinical trial	Tenoxicam (COX inhibitor)	No beneficial effects compared to placebo