Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Deletion of the φ-clamp significantly decreases the efficacy of the blockers. The multichannel conductances of WT PA63 (two curves on the left) and the F427A mutant of PA63 (two curves on the right) are inhibited by AmPrβCD (open symbols) and AMBnTβCD (filled symbols) blockers, with the IC50 values differing by orders of magnitude. Membranes were bathed by 0.1 M KCl solution at pH 6, and the applied voltage was 20 mV.
