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T. thermophila telomerase RNP biogenesis. T. thermophila TER is transcribed by RNA polymerase III. The binding of p65 stabilizes a kink in stem IV that optimally positions loop IV for TERT binding. The p65-TER–TERT ternary complex then interacts with a complex of p75, p50, p45, and p19 that recruits the single-stranded telomeric DNA-binding protein Teb1.
