Table III.
Associations between rs11614913, rs2910164 and rs3746444 SNPs and GC CIHM status.
| Variables (n) | rs11614913 genotype
|
rs2910164 genotype
|
rs3746444 genotype
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| TT | TC | CC | CC | CG | GG | AA | AG | GG | |
| CIHM status (127) | |||||||||
| p14 | |||||||||
| Unmethylated (68) | 19 | 35 | 14 | 37 | 22 | 9 | 47 | 17 | 4 |
| Hypermethylated (59) | 17 | 28 | 14 | 27 | 27 | 5 | 35 | 16 | 8 |
| p16 | |||||||||
| Unmethylated (101) | 30 | 48 | 23 | 50 | 39 | 12 | 64 | 27 | 10 |
| Hypermethylated (26) | 6 | 15 | 5 | 14 | 10 | 2 | 18 | 6 | 2 |
| CDH1 | |||||||||
| Unmethylated (40) | 11 | 21 | 8 | 22 | 16 | 2 | 27 | 9 | 4 |
| Hypermethylated (87) | 25 | 42 | 20 | 42 | 33 | 12 | 55 | 24 | 8 |
| DAP-kinase | |||||||||
| Unmethylated (13) | 3 | 7 | 1 | 4 | 5 | 4 | 8 | 4 | 1 |
| Hypermethylated (114) | 33 | 54 | 27 | 60 | 44 | 10 | 74 | 29 | 11 |
| No. of CIHM | |||||||||
| 0–1 (30) | 9 | 18 | 3 | 16 | 12 | 2 | 20 | 7 | 3 |
| 2–4 (97) | 27 | 45 | 25 | 48 | 37 | 12 | 62 | 26 | 9 |
rs11614913 TT+ TC vs. CC: no. of CIHM, 0–1 vs. 2–4; age- and gender-adjusted OR=3.67, 95% CI 0.98–13.72, p=0.05. rs11614913 TC vs. TT+CC: no. of CIHM, 0–1 vs. 2–4; age- and gender-adjusted OR=4.08, 95% CI 1.04–15.97, p=0.04. rs2910164 CC+CG vs. GG: DAP-kinase, unmethylated vs. hypermethylated; age- and gender-adjusted OR=5.48, 95% CI 1.30–23.10, p=0.02. rs2910164 CC vs. CG+GG: DAP-kinase, unmethylated vs. hypermethylated; age- and gender-adjusted OR=6.93, 95% CI 1.37–35.02, p=0.02. rs2910164 CG vs. CC+GG: DAP-kinase, unmethylated vs. hypermethylated; age- and gender-adjusted OR=4.24, 95% CI 0.87–20.78, p=0.07.