Figure 1.

Effect of dehydroascorbic acid on the virus yields. Confluent monolayers of HEp-2 (for HSV-1 and poliovirus) or MDCK (for influenza virus) cells were infected with each of the viruses at an MOI of 10 for HSV-1 and 7 for influenza virus or poliovirus. The infected cells were incubated in the medium containing the indicated concentrations of dehydroascorbic acid at 37°C for HSV-1 and influenza virus or at 35.5°C for poliovirus. At the end of infection, the amounts of infectious progeny viruses were determined and were normalized to the virus yield in the absence of the reagent. ○, HSV-1; ▵, influenza virus; □, poliovirus.