Figure 2.

Extracted data on reported annual rates of warfarin-associated ICH from major randomized controlled trials (RCTs; Atrial-Fibrillation-Investigators, 1994; SPAF-Investigators, 1994; Olsson, 2003; Albers et al., 2005; DiMarco et al., 2005; Connolly et al., 2006, 2009; Diener et al., 2010; Granger et al., 2011; Patel et al., 2011) of atrial fibrillation compared to non-inception cohort (Fihn et al., 1993; van der Meer et al., 1993; Go et al., 2003; Poli et al., 2009) and inception cohort studies (Landefeld and Goldman, 1989; Steffensen et al., 1997; Beyth et al., 1998; Hylek et al., 2007). *Subgroup analysis of patients with a previous history of ischemic stroke or transient ischemic attack in the RE-LY trial.