Table 4.

CROMIS-2 inclusion and exclusion criteria.

Inclusion criteria	Exclusion criteria
STUDY I: CROMIS-2 (AF)
Adult (≥ 18y; no upper limit) patients with a clinical diagnosis of non-valvular	Any MRI contraindications
AF (verified by ECG) and intention to treat with best practice oral anticoagulants (e.g., warfarin)	Previous ischemic stroke or TIA diagnosed by treating clinician Definite contra-indication to oral anticoagulation
Previous therapeutic use of oral anticoagulation	Serious head injury (resulting to loss of consciousness)
All patients must be able to have T2*-GRE MRI before (or within 1 week) of starting oral anticoagulation
STUDY II: CROMIS-2 (ICH)
Adult (≥ 18y) patients treated at participating centers with confirmed spontaneous ICH (on CT or MRI scans) with or without a history of anticoagulant use at the time of the ICH	Known underlying structural cause for ICH (e.g., arteriovenous malformation, tumor, cavernoma, intracranial aneurysm) Major head trauma (causing loss of consciousness and though to be sufficient to have caused the ICH) in previous 24 h