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. 2012 May 3;67(10):860–866. doi: 10.1136/thoraxjnl-2011-200953

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© 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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Effect of covariates on forced expiratory volume in 1 s as a percentage of predicted (%FEV₁). (A) Birth cohort effect in the final model. There is clear separation between the three most recent birth cohorts, with a successive increase in the intercept term at age 5 years. (B) Effect of pancreatic insufficiency and Pseudomonas infection on the predicted population trajectory for a person born in the 1988–1998 cohort. CF, cystic fibrosis; PA, Pseudomonas aeruginosa.