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. Author manuscript; available in PMC: 2012 Sep 19.
Published in final edited form as: Gastroenterology. 2007 Mar 24;132(5):1834–1851. doi: 10.1053/j.gastro.2007.03.038

Figure 1.

Figure 1

(A) Chemical structures of LPA and OTP. (B) Molecular models of OTP docked into the ligand-binding pocket of LPA receptors. (C) Ca2+ transients elicited by OTP and LPA in RH7777 cells stably expressing the individual EDG family LPA receptors. Wild-type RH7777 cells show no Ca2+ transients in response to LPA up to concentrations as high as 30 µmol/L (data not shown). (D) Synthesis of 3H-labeled OTP (see Materials and Methods for details).