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. Author manuscript; available in PMC: 2012 Sep 19.
Published in final edited form as: Biochim Biophys Acta. 2008 Jun 13;1781(9):571–581. doi: 10.1016/j.bbalip.2008.06.003

Fig. 4.

Fig. 4

The effect of IGF-I (A) and mitogen-activated protein kinase (MAPK) inhibitors (B) on early phenotypic modulation (PM) of vascular smooth muscle cells (VSMC). The segments of the thoracic aorta from wild-type (WT) mice were cultured in serum-free base medium supplemented with 2 ng/ml IGF-I and PD98059 (PD. 30 µM) plus SB203580 (SB, 20 µM) for times ranging from 0 to 12 h prior to RNA extraction. Quantitative RT-PCR was used to assess mRNA levels of marker genes. Values are means ± SEM for 3 replicates. *Denotes significant differences relative to the base medium (P<0.05).