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. Author manuscript; available in PMC: 2012 Sep 19.
Published in final edited form as: Bioconjug Chem. 1999 Jul-Aug;10(4):667–677. doi: 10.1021/bc9900136

Scheme 3. Synthesis of Sulfonyl-, Carboxy-, and Amine-Functionalized Congeners of the A3 Adenosine Receptor Selective Antagonists Based on Dihydropyridinesa.

Scheme 3

a Reagents: (a) NBS; (b) CH3OCH2Cl, Et3N; (c) K2CO3, acetone, reflux; (d) 1 N HCl, acetone, 45 °C; (e) H2N(CH2)2NH2, rt., 4 h; (f) N-hydroxysuccinimidyl biotin, DMF, rt.