Skip to main content
. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Amyotroph Lateral Scler. 2011 Nov;12(6):430–438. doi: 10.3109/17482968.2011.585163

Figure 1.

Figure 1

Serum antibody levels are elevated in sporadic amyotrophic lateral sclerosis (SALS) cases compared to healthy controls (HC) and subjects with other neurological disorders (OND). Sera samples for all subjects reported in this figure were obtained through the Clinical Trials Unit at Massachusetts General Hospital (Methods). Sera concentrations (μg/ml) of IgG antibodies against the SODox antigen (A) and WT-SOD1 antigen (B), and concentrations of IgM antibodies against the SODox antigen (C) and WT-SOD1 antigen (D), are shown in a dot-graph representation for the SALS, HC and OND cohorts. Each dot denotes the antibody concentration for a single subject; multiple subjects with the same concentration are represented by horizontal rows of dots. Mean antibody concentrations (Table 2) for the specified cohort are represented by gray bars. *Mean levels of anti-SODox IgG antibodies are significantly higher in SALS patient sera (0.11 μg/ml) compared to controls (0.07 μg/ml, p = 0.03).