A proposed model for canine A2a receptors deduced from the primary sequence, including seven transmembrane helices (I–VII), three extracellular loops (E-I–III), two histidinyl residues possibly involved in ligand binding (H), a sodium binding site (Na), and hypothetical disulfide bonds (S-S, residue numbers in italics) and thiol groups. Thiol of Cys82 is not shown.