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. Author manuscript; available in PMC: 2013 Sep 13.
Published in final edited form as: J Med Chem. 2012 Aug 21;55(17):7425–7436. doi: 10.1021/jm300351w

Figure 1.

Figure 1

Triazolopyrimidines with active anti-malarial activity. The initial HTS hit (1), an analog with improved plasma exposure (2), and analog with optimized plasma exposure and potency (3).