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Synthesis of Inhibitors 9, 10 and 12–15a
aReagents and conditions: CH3C(OCH2CH3)3, anhydrous DMF, reflux, 15 min - 1 h, 70–80 %; (ii) heat above 200 °C for 1 h, yield 65–70 %; (iii) POCl3, 30 –45 min, reflux; (iv) RNH2, EtOH, 15–18 h, room temp., yield 68–80 % (compounds 9–12) and 78 % (compound 10)
