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. Author manuscript; available in PMC: 2013 Sep 13.
Published in final edited form as: J Med Chem. 2012 Aug 21;55(17):7425–7436. doi: 10.1021/jm300351w

Figure 4.

Figure 4

Comparison of the series activity on PfDHODH vs P. falciparum whole cell assays. The log of the PfDHODH IC50 data are plotted versus the log of the P. falciparum EC50 data (in nanomolar). The plotted data include compounds 1, 2, 4–16 described in the Table 1. Compounds for which solubility limits prevented the quantitative determination of either the IC50 or EC50 have been left off the plot. Data were fitted by linear regression analysis where r2 = 0.84 and slope = 0.93.