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Pharmacokinetics and in vivo efficacy of 16 in mice. A. Pharmacokinetic profile of 16 after administration of a single oral or IP dose of 10 mg/kg. Drug concentration in micromolar is plotted versus time post dose. B. Mice were infected with P. berghei on day zero and 16 was dosed orally at 50 mg/kg 1× daily for 4 days beginning 24 h after infection. As a control chloroquine was dosed at 10 mg/kg orally using the same dosing schedule.
