. Author manuscript; available in PMC: 2013 Sep 13.

Published in final edited form as: J Med Chem. 2012 Aug 21;55(17):7425–7436. doi: 10.1021/jm300351w

Table 1.

Activity profiles of inhibitors 4–11^a

Compd
	Structure	Compound code names	IC₅₀ (μM) PfDHODH	EC₅₀ (μM) Pf3D7	IC₅₀ (μM) hDHODH	IC₅₀ (μM) PbDHODH
1^*		DSM1	0.047	0.076	> 100	0.23
2^*		DSM74	0.28	0.34	> 100	0.38
4		DSM154	> 100	>100	> 100	> 100
5		DSM155	> 100	> 50	> 100	> 100
6		DSM71	0.15±0.01	0.19 (0.15 – 0.25)	> 100	2.8±0.28
7		DSM96	4.8±0.7	5.2 (3.6 – 6.7)	n.d.	6.3±0.80
8		DSM68	0.4±0.09	0.91 (0.80 – 1.0)	> 100	3.3±0.4
9		DSM23	0.44±0.17	2.2 (1.2 – 3.7)	> 100	11±3.3
10		DSM70	> 100	> 12.5	n.d.	n.d.
11		DSM105	> 50	> 5	n.d.	>50
12		DSM25	4.8±0.38	3.2 (2.4 – 3.5)	n.d.	> 10
13		DSM78	27±6.3	> 10	n.d.	n.d.
14		DSM79	>25	3.2 (2.4 – 4.3)	n.d.	n.d.
15		DSM80	> 100	> 25	n.d.	n.d.
16		DSM151	0.077 ± 0.008	0.32 (0.30 – 0.35)	> 100	0.17 ± 0.018

Data for DSM1 and DSM74 were taken from^27,29 For enzyme data the error represents the standard error of the fit for n=3 data points per concentration; for parasite data the error displayed is the 95% confidence interval of the fit for n=3 or 4 data points per concentration.