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. Author manuscript; available in PMC: 2013 Sep 13.
Published in final edited form as: J Med Chem. 2012 Aug 21;55(17):7425–7436. doi: 10.1021/jm300351w

Table 2.

In vitro metabolism in human and mouse microsomes

Compd Degradation half-life (min) In vitro CLInt (mL/min/mg protein) Predicted EH Putative metabolites
Human
2 * 230 0.0075 0.29 P+16
16 368 0.0047 0.21 None detected
Mouse
16 51.8 0.034 0.59 None detected
*

data were previously reported in Gujjar et al. 29 Data represent single point measurements.