FIG. 2.
Mitochondrial toxicity of compounds already described to cause mitochondrial dysfunction. Isolated mouse liver mitochondria were untreated (◆) or treated with increasing concentrations (•, •, ◼, and ▲; range indicated on the graphs) of alpidem, diclofenac, perhexiline maleate, and troglitazone, or with positive controls (◼). Mitochondrial swelling, loss of ΔΨm, cytochrome c release, and inhibition of oxygen consumption were thus assessed as described in Materials and Methods and Figure 1.