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Mitochondrial toxicity of drugs with no previously reported mitochondrial liability. Isolated mouse liver mitochondria were untreated (◆) or treated with increasing concentrations (•, •, ◼, and ▲; range indicated on the graphs) of lumiracoxib, nilotinib, and saquinavir, or with positive controls (◼). Mitochondrial swelling, loss of ΔΨm, cytochrome c release, and inhibition of oxygen consumption were thus assessed as described in Materials and Methods and Figure 1.
