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. Author manuscript; available in PMC: 2013 Sep 15.
Published in final edited form as: Clin Cancer Res. 2012 Jul 18;18(18):4997–5007. doi: 10.1158/1078-0432.CCR-11-2322

Fig. 6. Molecular markers and drivers of Wnt activation identified in the two Wnt-related subclasses of HCC.

Fig. 6

Markers: CTNNB1 subclass shows the gold-standard marker of Wnt pathway activation (i.e β-catenin localization in the nucleus or cytoplasm), while common Wnt pathway target genes included in public databases (i.e Classical Wnt target genes) are enriched in Wnt-TGFβ subclass. Drivers: CTNNB1 subclass has the most commonly descrived driver of Wnt activation (i.e CTNNB1 exon3 mutations), while few other activating alterations characterize this class in comparison to Wnt-TGFβ samples which show clear activating alterations at the gene expression level (i.e overexpression of FZD7, FZD6, TCF4, FRAT2 & ARBB2).