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. 2012 Sep 19;7(9):e45531. doi: 10.1371/journal.pone.0045531

Figure 3. Concentration-dependent inhibition of proton-gated currents by WIN55,212-2.

Figure 3

A. Sequential current traces illustrate the inhibition of proton-induced currents by different concentration of WIN55,212-2 (WIN) on a DRG neuron with membrane potential clamped at −60 mV. Proton-gated currents were elicited by application of pH 5.5 for 5-s durations. The pretreatment time for WIN55,212-2 was 60 s. B. WIN55,212-2 decreased proton-gated currents (IpH5.5) in a concentration-dependent manner (10−10–10−6 M). Each point represents the mean ± SEM of 7–10 neurons.