Figure 6. Effect of WIN55,212-2 on proton-evoked action potentials of rat DRG neurons.

A. Original current and action potentials recordings from the same DRG neuron. Left panel, pH 5.5 induced an inward current with voltage-clamp recording. Right panel, pH 5.5 produced action potentials with current-clamp recording in the same neuron. The pretreatment of WIN55,212-2 (WIN, 10⁻⁷ M) decreased the acid-induced the number of action potentials. B. Bar graph shows the effect of WIN55,212-2 on the number of action potentials produced by pH 5.5 acid perfusions. After 30 min washout of WIN55,212-2, acid-evoked action potentials recovered to control condition. *P<0.05, paired t-test, compared with control, n = 8/each column.