Figure 1. Representative cystometrographies of control and FFR responses to intravesical instillation of acidic ATP solution (5 mM, pH 3.3) alone or after pre-treatment with capsaicin.

A. Reproducible effects of infused functional bladder capacity reduction were observed by intravesical infusion of acidic ATP solution in controls. B. A representative trace of infused functional bladder capacity reduction and increased provoked phasic contractions in FFRs with NDF that is repeatable during intravesical stimulation with acidic ATP solution. C. The response to acidic ATP solution stimulation of the bladder is inhibited in the control rats pretreated with capsaicin. D. Reflex micturition from acidic ATP solution stimulation of the bladder in FFRs is also inhibited by capsaicin pretreatment.