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. 2012 Sep 19;7(9):e45628. doi: 10.1371/journal.pone.0045628

Figure 2. Fibrinogen heterozygosity protects from progression of kidney dysfunction and apoptosis following IRI.

Figure 2

Male wild type (Fg+/+), heterozygous (Fg+/−) and knock out (Fg−/−) mice were subjected to IRI and assessed for kidney injury parameters (n = 6/group/time point) A) Serum creatinine (Scr), Blood Urea Nitrogen (BUN) and urinary Fg levels. B) Representative histopathological images using periodic acid-schiff (PAS) staining and quantitative necrosis score represented graphically on the right. C) Apoptotic cells (green) determined by TUNEL assay. Percentage of positive staining TUNEL nuclei is represented graphically on the right of photomicrographs. *represents p<0.05 in comparison to sham; #represents p<0.05 as compared to wild type within the time point and !represents p<0.05 as compared to heterozygous within the time point as determined by one-way ANOVA. Bar represents 10 µm.